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BOF 87
Pathology of rheumatoid arthritis, all are true, except:
1-the earliest change is swelling and congestion of the synovial membrane and the underlying connective tissue
2-the infiltrating T lymphocytes are mainly CD8 positive cells
3-subcutaneuos nodules consist of central fibrinoid necrosis surrounded by palisading mononuclear cells
4-the muscles adjacent to the inflamed joints atrophy and there may be a low grade lymphocytic myositis
5-effusions into the joints are mainly seen in active disease

 

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