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BOF: 158

A 52 year old male presents with a history of yellow discolouration of the skin, itch and passage of dark urine and pale stools.

He is known to have hypertension, diabetes mellitus and schizophrenia and is on multiple drugs

Clinical examination reveals jaundice and excoriations but no other positive physical findings

Abdominal ultrasound does not show dilated bile ducts

Alanine aminotransferase 120 U/L

Alkaline phosphatase 386 U/L

Bilirubin 132 µmol/L

In this patient which one of the following drugs could be responsible for his condition?

a)     Atenolol

b)     Bendroflumethiazide

c)     Diazepam

d)     Chlorpromazine

e)     Metformin

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